Role of lipids, ionized calcium, and alkaline phosphatase in progress of pregnancy induced hypertension - A prospective study in Kolkata

Background: Pregnancy induced hypertension may complicate to preeclampsia and eclampsia. The pathophysiology of the former is still confusing, many authors suggested different opinions, and indicated different parameters for the prognosis of this. Aim: To evaluate serum HDL and LDL cholesterol, alkaline phosphatase, ionized calcium in pregnancy induced hypertension patients. Materials and methods: We had selected normal non-pregnant females (Group 0), pregnant normotensive females (Group I) and pregnancy induced hypertensive females (Group II). All the above mentioned parameters were estimated in them. Statistical analysis was done by SPSS 17 software; ANOVA and post hoc Bonferroni analysis were used to compare them. Results: Significant increase of LDL and alkaline phosphatase as well as significant decrease of HDL and ionized calcium were found in Group II females. Conclusion: HDL and LDL cholesterol, alkaline phosphatase, ionized calcium can indicate the severity of gestational hypertension. Normalization of those parameters can prevent the complications like preeclampsia and eclampsia.